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Product Overview



Supports Normal Intestinal Tight Junction Function

GI Calm supports normal function of epithelial tight junctions in the gut. GI Calm is ideal for supporting normal GI health and function in the face of stressors such as travel, training and performance. When other digestive supplements have failed, it is time to try GI Calm. Benefits include:

  1. Supports normal tight junction function in the gut.
  2. Helps support structural integrity of the gut lining.
  3. Enhanced gut function.
  4. Supports normal GI health and function.
  5. Enhanced immune function.
  6. Promotes the body’s innate resistance to pathogens.
  7. Keeping the digestive tract functioning properly which may help reduce the possibility of colic.

Key Ingredients:

  • Butyric Acid
  • L-Glutamine
  • Peptides
  • Antioxidants


  • Feed 1 scoop (33 grams) twice daily. If results are not achieved after 7 days, mix 2 scoops (66 grams) into feed twice daily.
  • Please consult with us regarding the best approach to address intestinal health for your horse.

Ingredients: Dried Bovine Colostrum, Dried Bacillus subtillus, L-Glutamine, Beet Root Powder, Magnesium Carbonate, Butyric Acid, Ascorbic Acid, L-Citrulline, Choline Bitartrate, (d-alpha-tocopherol, gamma-tocopherol (sources of natural vitamin E)), L-Theanine, L-Tryptophan, N-Acetyl-Cysteine, Thiamin Mononitrate, Vitamin B-12, Niacin, Pyridoxine, Folic Acid, Stevia, Peppermint Flavor.



(8 reviews) Write a Review

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  • 5
    GI Calm

    Posted by Sandy Rose on Oct 28th 2021

    Love this product. I can tell a difference in the demeanor and performance of my driving pony. Haven’t had to use any other gastric supplements since starting on this product and use it on all of my performance ponies now.

  • 5
    20 year old Warmblood gelding

    Posted by S Schoettle on Nov 23rd 2020

    GI Calm finally helped my gelding - I have a new horse. My gelding has had digestive problems since I bought him as a 6 year old. Frequent gas colic, on and off diarrhea, excessively smelly manure, and retention of fluid in his sheath and legs. Have tried many things over the years and ruled out ulcers and nothing ever helped. After two weeks, he was less gassy, manure smelled less and sheath was normal size. Now after a month, he is even better. Consistent manure, less smell, and has more energy. Thank you!

  • 5
    I am flabbergasted by the results!

    Posted by Kara P on Jul 29th 2020

    ​Dr. Jyme, I am about 2 months in on GI calm/modified hind gut. I am flabbergasted by the results. My vet said last week “what did you do to this horse, I have never seen him look or travel this good”. He always twists his right hock and she said its gone. I went to my farrier 2 weeks ago and he said “this is the best I have ever seen your horses move”. I honestly did not think a supplement would make that big of a difference. I have literally tried everything- supplements to every prescription and nothing else seemed to make much of a difference. Thank you!

  • 5
    GI Calm

    Posted by J. WYZKIEWICZ on Dec 21st 2019

    My Stella is a 20 year old Mare that's had chronic diarrhea for 1.5 years. After spending thousands of dollars on the expensive pastes, meds, scopes, ultrasounds to no avail, I found Dr. Bill Vandergrift's video on Leaky Gut syndrome. Stella was a textbook case. This was my last chance with Stella, for she was so sick, that I did not want her nor I to go through another Michigan winter with liquid diarrhea. In October we began GI Calm and changed her diet to primarily Timothy grass pellets, and only 2 flakes of hay per day. We mixed GI Calm in apple sauce with a new beet pulp grain feed, with sucralfate, and a ph regulator powder. Within 2 weeks, we saw her coming back. Now for Christmas, the Boss Mare is back! Stella went from the verge of death to having the energy, muscle tone, and looks of a teenager! She's at full weight and is entirely herself. We are making the transition to regular diet slowly, and are now switching to the ADR maintenance powder with high anticipation for pasture grass in the Spring to complete the transition. In conclusion, expensive pastes, powders, and meds do not work alone. Changing her diet to grass pellets along with the GI Calm powder of Dr. Bill's research, has saved my Stella and I am so very grateful. My highest recommendation....and please don't give up until you try this regimen. ❤

  • 5
    Ulcers, hind gut and anxiety

    Posted by Shelly on Jul 29th 2019

    Dr. Bill recommended me to use this product for 60 days on my running bred mare that I compete on (Barrels) due to her having gut issues and high anxiety at the gate. At first she wouldn't eat it in her feed (she's a picky girl but I believe it is due to her gut hurting) so I would spoon it in her mouth and then feed her. Two weeks of doing that then I tried putting it back in her feed, she now eats it right up. We are on her second month and I believe this has tremendously helped her! She is back to walking in the gate and CLOCKING again YAY!! Great product!

  • 5
    Chronic Diarrhea - Leaky Gut

    Posted by Lexi Groen on Jul 18th 2019

    I got Addy 3 years ago as a 3 year old. Ever since the first day I picked her up she had diarrhea. As the years went by she got worse and her personality started changing and she became very difficult to work with. We tried everything to clear up her diarrhea and make her happy again. Nothing worked until my sister had me listen to a pod cast that had Dr. Jyme Nichols talking about Leaky Gut. I started Addy on GI calm and Stride 101. And WOW! Within the first week her diarrhea was becoming more solid. Her personality was beginning to calm and become more personable again. We believed Addys case of leaky gut was more severe so she will take a little longer to heal from it. We are just starting month 3 but GI Calm has been a life saver and a life changer for Addy and myself.

  • 4
    GI Calm

    Posted by Lauren on Apr 27th 2019

    Have been using it for about a month. It isn't a miracle cure for my gelding with a leaky gut but I see marked improvement.

  • 5
    Answered prayer

    Posted by Chris on Nov 28th 2018

    My mare has had chronic diarrhea for 2.5 years now. We have tried everything and I mean everything. Thousands of dollars spent and nothing has helped. We were at the point to where we had to make a decision whether her quality of life was worth letting her go through another year of pain as we watched my once vibrant and happy horse waste away. My old vet from where we used to live suggested trying ADR as a last resort and that led to Dr. Bill suggesting the GI Calm based on the symptoms my mare was having. Just 6 weeks into using GI Calm my mare’s diarrhea has improved significantly. It’s the first time I have seen it like this in 2.5 years. It’s not perfect yet, but it’s definitely improved and I know she is on her way to being healed. She trotted around the pasture and bucked and kicked out a few days ago for the first time in 2 years and I can see her old mischievous attitude coming back. She had gotten to where she wouldn’t eat anymore and now she paws and gets frustrated if we don’t have her feed bucket in front of her when she gets in her stall. I think I’m getting my old horse back! All I can say is thank you to Dr. Bill and your team for working with me and all that you have done. Your team gets my orders out in 1 day turnaround and gives amazing customer service. I know it’s going to take some time to get my mare completely well, but I now have hope and that’s something I had lost. Thank you from the bottom of my heart!